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      • NEWS
        • Financing Round Mister Spex
        • immatics Familie-Hansen-Preis 2013
        • 4-Antibody AG + Ludwig Institute
        • Vertrauen in Mister Spex gestärkt
        • Bauckhage: Kino-Marketing und Wahlkampf
        • E-commerce heavy weight division
        • immatics wins 2012 TiE50 Award
        • Starboard $13 Million Series B
        • MoviePilot Seals $7M
        • Quantenna Raises $79 Million
        • Grazia Award 2012
        • Launch of Starboard Storage Systems™
        • XConnect and IPV Collaborate
        • With a Click of the Remote
        • Statista zieht es nach New York
        • B2X in North America
        • Lothar Späth berät Grazia
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      NEWS

      14. May 2013

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      Leading German online optician Mister Spex secures 16 million Euro investment to support international growth ...

      7. March 2013

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      immatics’ Mitgründer Professor Dr. Hans-Georg Rammensee erhält den Familie-Hansen-Preis 2013   Familie-Hansen-Preis als Anerkennung für ...

      29. January 2013

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      Expand Oncology Antibody R&D Program with Three New Targets 4-Antibody AG and the Ludwig ...

      24. January 2013

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      Starkes Wachstum: Online-Optiker Mister Spex erreicht 26 Mio. Euro Jahresumsatz Vertrauen in Online-Brillenkauf und Marke ...

      4. December 2012

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      Zwei Tage, die über Erfolg und Misserfolg entscheiden Von Tobias Bauckhage   Hollywoods Marketing-Strategen stehen ...

      8. November 2012

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      immatics’ renal cancer vaccine IMA901 completes phase 3 patient recruitment and is granted US orphan ...

      17. October 2012

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      Mister Spex erweitert Logistikzentrum und schafft Arbeitsplätze am Standort Berlin Marktführender Online-Optiker bezieht ...

      16. October 2012

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      'Love at First Touch': URBANARA eröffnet Pop Up Shop in Berlin   URBANARA, die Online-Marke ...

      12. July 2012

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      mysportgroup enters the e-commerce heavy weight division   Award-winning mysportgroup raised €13.5m in its Series ...

      1. June 2012

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      immatics presents encouraging overall survival data from a phase 2 study in Advanced Colorectal Cancer ...

      25. May 2012

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      immatics wins 2012 TiE50 Award immatics chosen as a leading company in the life ...

      14. May 2012

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      Starboard Storage Systems Closes $13 Million Series B Round of Funding   Accelerates Market Momentum ...

      10. May 2012

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      MoviePilot Seals $7M Series B Funding Led By DFJ Esprit   It’s easy to miss ...

      17. April 2012

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      Quantenna Communications Raises $79 Million Led by RUSNANO and Sequoia Capital   Oversubscribed Funding Round ...

      17. April 2012

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      Online-Optiker Mister Spex expandiert nach Skandinavien - Berliner E-Commerce-Unternehmen launcht schwedischen Online-Shop für Kontaktlinsen, Brillen ...

      12. April 2012

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      immatics appoints Dr Rainer Kramer as Chief Business Officer   immatics biotechnologies GmbH, a clinical-stage ...

      4. April 2012

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      Starboard Storage Systems and Acronis Bring Optimized Storage Solutions to Small and Medium Enterprises   ...

      29. March 2012

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      Geschäftspläne von HHL-Studenten in Medizin und E-Commerce erfolgreich Businesspläne zur Einführung eines Arzneimittels zur Behandlung ...

      28. March 2012

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      Promark Technologies to Offer Starboard Storage Systems   Industry Leading Margins for Resellers, New Starboard ...

      20. March 2012

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      Large Binocular Telescope Observatory Looks to the Stars with Purchase of Starboard Storage AC72   ...

      13. February 2012

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      Starboard Storage Systems™ Announces AC72 to Address Small and Medium Enterprise Need for Mixed Workload ...

      13. February 2012

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      A team of storage industry leaders from Compellent, HP, LeftHand Networks, LSI and Sun today ...

      1. February 2012

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      Deutschlands größter Online-Händler für Markenbrillen gehört zu Top-Ten-Unternehmen der Optikbranche    Der Online-Optiker Mister Spex ...

      31. January 2012

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      XConnect and IPV Collaborate to Reduce Cost, Complexity of Video Calling and Conferencing     ...

      24. January 2012

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      immatics presents positive Phase II results with its therapeutic cancer vaccine IMA910 in patients with ...

      5. December 2011

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      With a Click of the Remote, Impulse Purchases   Giving television viewers the ability to ...

      22. November 2011

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      Berliner Online-Optiker erhält Auszeichnung im Rahmen von „125 Jahre Versandhandel“ bei Insight E-Commerce in Leipzig ...

      7. November 2011

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      TELEFÓNICA MAKES STRATEGIC INVESTMENT IN QUANTENNA Telefónica Digital through its Venture Capital arm joins other ...

      3. November 2011

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      mysportgroup (Privatesportsale GmbH), Betreiberin der eCommerce-Angebote www.mysportbrands.de und www.mysportworld.de, konnte eine signifikante Finanzierungsrunde zur Fortsetzung ...

      2. November 2011

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      Delivery Agent Raises $35.5 Million Led by Intel Capital with Liberty Global, and Grazia Equity ...

      19. September 2011

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      4-Antibody AG Meets Next Milestone in Boehringer Ingelheim Collaboration 4-Antibody AG today announced the ...

      16. September 2011

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      Mister Spex (www.misterspex.de) erhält Gütesiegel „EHI Geprüfter Online-Shop“ und baut 3D-Anprobe aus Das EHI-Gütesiegel ...

      12. September 2011

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      Das Hamburger Statistikportal Statista expandiert in die USA und eröffnet eine Niederlassung in New York ...

      1. September 2011

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      Ehemaliger Metaversum-Mitgründer Mirko Caspar neu als Geschäftsführer für Marketing und Vertrieb beim größten deutschen Online-Shop ...

      24. August 2011

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      “150 Leute, 35 Grad und 80 % Luftfeuchtigkeit – das macht Spaß!” Benjamin Esser von ...

      22. August 2011

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      Berliner Online-Brillenhändler startet deutschlandweites Partnernetzwerk mit lokalen Augenoptikern   Als erster deutscher Online-Brillenshop kooperiert Mister ...

      16. August 2011

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      AirTies Partners with Quantenna to Deliver Wireless HD Video Streaming with Unparalleled Range and Performance ...

      3. August 2011

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      Leader in Ultra-Reliable 802.11n Wi-Fi Home Video Networking is Lauded for Third Consecutive Year   ...

      11. July 2011

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      Finanzspritze für Urbanara - Online-Shop sammelt siebenstellige Summe ein   “Qualitativ hochwertige Heimtextilien und Wohnaccessoires” ...

      29. June 2011

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      XConnect Vice President John Wilkinson Honored by Global Telecoms Business for Second Consecutive Year   ...

      20. June 2011

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      Online-Anprobe von Brillen im Internetshop erstmals in 3D möglich Versandhändler Mister Spex geht als erster ...

      24. May 2011

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      4-Antibody AG Forms Multi-target Oncology Research and Development Alliance with the Ludwig Institute   4-Antibody ...

      23. May 2011

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      Mister Spex zählt zu schnellstwachsenden Internetunternehmen Europas   Berliner Online-Optiker belegt bei GP Bullhound Media ...

      19. May 2011

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      B2X Care Solutions launches in North America   After-sales services provider B2X Care Solutions (http://www.b2xcare.com) ...

      12. May 2011

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      Mister Spex rockt im TV - Der neue Sonnenbrillenspot geht heute on air   Der ...

      11. May 2011

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      Adconion Media Group Completes Multi-Million Dollar Financing with Silicon Valley Bank   Adconion Media Group, ...

      11. April 2011

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      immatics to receive support from Pfizer for its pivotal Phase III study (IMPRINT) with IMA901, ...

      6. April 2011

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      New Industry Research Confirms RELDATA Is Positioned to Continue Significant Growth Key Findings from Storage ...

      31. March 2011

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      http://www.gruenderszene.de Interview mit einem VC: Grazia – Jochen Klüppel im Gespräch Sie sind ...

      28. March 2011

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      Online-Brillenhändler startet Partnerprogramm mit stationären Optikern, um Service für die Kunden weiter zu verbessern   ...

      4. February 2011

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      Berliner Online-Brillenhändler in Brüssel von Gerhard Schröder als eines der wachstumsstärksten Unternehmen ausgezeichnet   Mister ...

      2. February 2011

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      Berliner Online-Brillenhändler erzielt im Jahr 2010 rund 11 Millionen Euro Umsatz Drei Jahre nach ...

      31. January 2011

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      RELDATA Inc. (www.RELDATA.com), the innovation leader in unified block and file storage solutions over iSCSI, ...

      11. January 2011

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      RELDATA Secure $4 M in Series B for Innovative Data Storage Solution   RELDATA, a ...

      5. January 2011

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      Quantenna Features Award-Winning 4x4 MIMO 802.11n Wi-Fi Home Networking Technology at CES 2011   Winning ...

      29. October 2010

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      Mister Spex siegt beim Deutschen Unternehmer Preis 2010 Online-Brillenhändler überzeugt in der Kategorie Startup ...

      19. October 2010

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      Verlagsgruppe Handelsblatt baut mit Statista Paid-Content-Bereich aus   Die Verlagsgruppe will Entscheiderm zukünftig mehr ...

      21. September 2010

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      immatics raises €54 million to advance its late stage clinical therapeutic cancer vaccine portfolio ...

      10. September 2010

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      Über 7 Mio. Euro für Mister Spex Mister Spex, Deutschlands größter Online-Versandhändler für Markenbrillen ...

      12. July 2010

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      RELDATA Named Tech Awards Circle Winner / Unified Block and File Storage Solutions Provider Selected ...

      18. June 2010

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      RELDATA Selected as AlwaysOn East Top 100 Winner for Cloud and Infrastructure Technology Unified Storage ...

      7. June 2010

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      On June 24, 2010, the 8th annual Grazia Equity Business Plan Competition was hosted at ...

      5. June 2010

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      immatics announces Phase II Results with its Therapeutic Cancer Vaccine IMA901 in Patients with Advanced ...

      2. June 2010

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      Online-Brillenhändler Mister Spex zählt zu "Red Herring 100 Europe" Unternehmen Red Herring Europe Award ...

      2. June 2010

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      immatics enters Collaboration with the National Cancer Institute (NCI) to Advance the Development of IMA950 ...

      16. February 2010

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      immatics Enters Collaboration with Cancer Research UK to Develop Multi-target Rationally Designed Therapeutic Cancer Vaccine ...

      4. February 2010

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      XConnect revenue doubled in 2009   XConnect, the leader in next-generation interconnection and carrier ENUM-registry ...

      1. February 2010

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      Online-Brillenhändler Mister Spex hat 2009 Brillen und Kontaktlinsen für rund 4,5 Millionen Euro verkauft – ...

      26. January 2010

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      RELDATA UNIFIED STORAGE NAMED ONE OF “100 COOLEST CLOUD COMPUTING PRODUCTS” BY EVERYTHING CHANNEL’S CRN ...

      20. January 2010

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      RELDATA (www.reldata.com), a provider of software-centric unified storage solutions, announced today its new RELDATA Partner ...

      14. January 2010

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      HORIZONT und Statista starten Portal HORIZONTstats.de Premium-Initiative für Paid Content Auf HORIZONTstats.de gibt es ...

      9. December 2009

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      First Chip Supplier to Offer 4x4 MIMO Wi-Fi Devices Will Play Active Role in One ...

      2. December 2009

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      Conergy Solar Factory in Frankfurt (Oder): Three Years "Quality Made in Germany"     Ramp ...

      20. November 2009

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      Investoren-Einstieg unterstützt weitere Wachstumsstrategie   Der Stuttgarter Finanzinvestor Grazia Equity ist beim After Sales Dienstleister ...

      16. November 2009

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      Allzu viele Partner bei der Finanzierung können das Wachstum eines jungen Unternehmens stören. Es kommt ...

      19. October 2009

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      Mit Mister Spex bringt Dirk Graber den Durchblick zurück. Wir haben ihn zu seiner Arbeit ...

      5. October 2009

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      Statistik-Portal startet heute sein Premium-Angebot, das für 29,90 Euro pro Monat die Verwendung exklusiver Daten ...

      1. October 2009

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      "Gründerszene ist sehr unterentwickelt" Von Claus G. Schmalholz Lothar Späth, zuletzt Vorsitzender der ...

      29. September 2009

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      immatics biotechnologies GmbH today announced the appointment of Dr Carsten Reinhardt as Chief Medical Officer ...

      22. September 2009

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      RELDATA Introduces Next Generation 9240i Unified Storage System Powered by Enhanced RELvos 2.4 Virtualization OS ...

      16. September 2009

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      Venture capital firms Venrock Associates, Accel Partners, Grazia Equity and Crescent Point Group all participated ...

      9. September 2009

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      Nanosolar Completes Panel Factory, Commences Serial Production   Today Nanosolar demonstrated the completion of its ...

      9. September 2009

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      Nanosolar Unveils Nanosolar Utility Panel™ Technology   In conjunction with today's inauguration of our panel-assembly ...

      9. September 2009

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      NREL Certifies 16.4% Nanosolar Foil Efficiency   It was May 2006 when we last released ...

      10. August 2009

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      immatics biotechnologies GmbH today announced that the company obtained European patent protection for the composition ...

      27. July 2009

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      Portal will Informationen für Marketingentscheider bündeln Mit einem neuen Seitenkonzept will das Statistik-Portal „Statista“ ...

      21. July 2009

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      RELDATA Named a CRN Emerging Technology Vendor RELDATA's unified storage solutions provide channel partners ...

      7. July 2009

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      Ehemaliger Ministerpräsident arbeitet für Venture Capital-Geber: Lothar Späth berät Grazia Equity Prof. Dr. h.c. ...

      3. July 2009

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      Grazia Equity Award für die beste Geschäftsidee an der HHL   Von einer Charityplattform ...

      30. June 2009

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      Conergy sells solar portfolio with a capacity of 10.7 MWp   ...

      17. June 2009

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      immatics biotechnologies significantly improves XPRESIDENT™ technology platform. immatics biotechnologies today announced the completion of ...

      10. June 2009

      >

      Australia: Planning Approval for 282 Wind Turbines   EPURON reaches key milestone for the largest ...

      8. June 2009

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      Conergy Deutschland GmbH sells the Heimpersdorf megawatt solar park to investor   Conergy Deutschland GmbH ...

      29. May 2009

      >

      moviepilot.de: Führender personalisierbarer Entertainmentguide für Kino, DVD und TV schließt zweite Finanzierungsrunde ab Berlin, 29.05.2009 ...

      19. May 2009

      >

       Solarstrom von Conergy reduziert Kosten für Wasserversorgung in Kalifornien   • 1,6 MWp Solarpark im ...

      14. May 2009

      >

      Statista startet Geschäftskunden-Angebot Statistik-Portal bietet umfassende Markenreports und kostengünstige Online-Umfragen Ausführliche Analysen zu ...

      12. May 2009

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      Quantenna Communications Names David French as New CEO   Founder Behrooz Rezvani Continues with Company ...

      8. May 2009

      >

      Solar energy from the region, for the region: Conergy Deutschland inaugurates a megawatt class thin-film ...

      8. May 2009

      >

      Solar energy from the region, for the region: Conergy Deutschland inaugurates a megawatt class thin-film ...

      28. April 2009

      >

      XCONNECT NAMES RICHARD SHOCKEY, ENUM PIONEER AND IP COMMUNICATIONS EXPERT, TO ADVISORY BOARD   Appointment ...

      27. April 2009

      >

      RELDATA EXPANDS ITS SALES ORGANIZATION Industry Veteran Peter Cmaylo joins RELDATA as VP Sales ...

      22. April 2009

      >

      XCONNECT EXPANDS GLOBAL ALLIANCE FEDERATION SERVICES   Innovations Bring Communications Service Providers More NGN ...

      21. April 2009

      >

      XCONNECT RECEIVES 2009 NGN LEADERSHIP AWARD FROM NGN MAGAZINE   Global Alliance Honored for Outstanding ...

      20. April 2009

      >

      Must-have-Accessoires: Hält die Brille mit der It-Bag Schritt?     Das Mister Spex "Brillen-Mode-Barometer" analysiert ...

      8. April 2009

      >

      Metaversum and Twinity has been elected a Red Herring 100 Europe Winner 2009 With ...

      24. March 2009

      >

      OVERGENCE SESSION MANAGER LATEST VOIP-PEERABLE DEVICE CERTIFIED XCONNECT-READY   Testing for ENUM Query Compatibility Streamlines ...

      11. March 2009

      >

      NETNUMBER TITAN SERVER CERTIFIED XCONNECT-READY, SIMPLIFYING VOIP FEDERATION-BASED INTERCONNECTION       Interoperability Testing Streamlines ...

      2. March 2009

      >

      immatics completes patient recruitment in phase II study with cancer vaccine IMA901 for renal cell ...

      24. February 2009

      >

      Quantenna Raises $15 Million in Series D Financing Round Quantenna Communications, Inc., a leader ...

      24. February 2009

      >

      RELDATA AND XYRATEX ENABLE HETEROGENEOUS STORAGE RELDATA 9240 and Xyratex F6412E RAID system certification ...

      26. January 2009

      >

      immatics wins 29th German Industry’s Innovation Award (Innovationspreis der deutschen Wirtschaft)   Tuebingen, January 26, ...

      26. January 2009

      >

      The Growing Market for Solar Cells     Printing is playing a key role in ...

      26. January 2009

      >

      SMC Networks Announces 10G Certification with RELDATA’s Unified iSCSI Storage System to Enable High-Performance Virtualized ...

      24. January 2009

      >

      VC Investing Drops For 2008, But Green Grows Venture capital investment shrank in 2008 ...

      21. January 2009

      >

      Feeding In Renewable Energy Breakthroughs What renewable energy really needs is a shift to ...

      5. September 2008

      >

      Wowereit Opens Virtual Berlin in Twinity     Metaversum GmbH, developer and operator of the ...

      27. August 2008

      >

      Nanosolar outshines the competition with a $ 300M financing Chris Morrison Thin-film solar ...

      24. January 2012

      immatics: positive results with therapeutic cancer vaccine

      immatics presents positive Phase II results with its therapeutic cancer vaccine IMA910 in patients with advanced colorectal cancer at the ASCO Gastrointestinal Cancers Symposium

       

      Study shows a consistent association between immune response to IMA910 and all clinical endpoints and an excellent tolerability profile

       

      immatics biotechnologies GmbH, a clinical-stage biopharmaceutical company developing advanced therapeutic vaccines that are active against cancer, announced positive results from its Phase II clinical trial with IMA910 in patients with advanced colorectal cell carcinoma (CRC) which were presented at the Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology (ASCO) in San Francisco. IMA910 comprises 13 tumor-associated peptides (TUMAPs) identified directly from patients suffering from colorectal cancer.

       

      The IMA910 study recruited 92 patients with advanced/metastatic CRC who had shown no progression following 12 weeks of first line oxaliplatin-based chemotherapy and who had decided to take a so called ‘drug holiday’ from their chemotherapy regimen. Patients received one single infusion of cyclophosphamide (CY) as immunomodulator prior to the first vaccination with the multi-peptide vaccine IMA910. They were treated with IMA910 plus GM-CSF and with or without an additional immunomodulator imiquimod. All patients received up to 16 vaccinations with IMA910 over a period of 9 months. The trial was conducted at 51 centers in 9 European countries.

       

      The study measured overall survival, disease control rate, T-cell responses to IMA910, the effect of imiquimod on immune response, the association of immune response with clinical benefit, and safety and tolerability.

       

      The data from the study confirmed that IMA910 is able to stimulate relevant immune responses against the tumor-associated peptides (TUMAPS) in IMA910 in the majority of patients vaccinated. Intriguingly, when looking at the clinical outcome of patients who had detectable T cell responses against two or more of the tumor-derived peptides (TUMAPs) contained in IMA910, a consistently better clinical outcome (disease control, progression-free survival and overall survival) was observed compared to those who did not have a detectable multi-T-cell response. Moreover patients who mounted both CD8+ and CD4+ multi-T-cell responses did not reach the median survival after more than 28 months of follow-up compared to a 16 months median survival time in those who did not (HR 0.53; p=0.088). In addition, the data presented show that IMA910 is very well tolerated with injection-site reactions being the most frequent side effect seen.

       

      Carsten Reinhardt, Chief Medical Officer of immatics said: “The Phase II trial results with IMA910 in this challenging setting in patients with advanced colorectal carcinoma are very encouraging. The data that we have generated show a clear association between the patient’s ability to mount an immune response to the tumor associated peptides (TUMAPS) in IMA910 and overall survival. Since the baseline characteristics of immune responders and non-responders were very similar in terms of risk factors, this strongly suggests a true clinical activity of this novel vaccine”.

       

      Paul Higham, CEO of immatics said: “The fact that we have now generated positive Phase II results with our two lead therapeutic vaccines, IMA901 for renal cell carcinoma and IMA910 for colorectal cancer highlights the power of our TUMAP based approach and the ability of our XPRESIDENT™ platform to generate further exciting treatment options for a broad range of cancers.”

       

      The poster presented at the Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology (ASCO) in San Francisco contains a more detailed analysis of the survival, safety and immune response data generated with IMA910 in this Phase II study. The poster can be downloaded at www.immatics.com.

       


      For additional information on immatics please visit www.immatics.com or contact:

       

      Paul Higham, CEO
      Katrin Eckert, Assistant to the Management
      immatics biotechnologies GmbH
      Phone: +49-7071-5397-110
      E-mail: media@immatics.com

       

      Citigate Dewe Rogerson
      David Dible / Chris Gardner / Sita Shah
      Phone: +44 207 638 9571
      E-mail: david.dible@citigatedr.co.uk


      About IMA910

      IMA910 is therapeutic cancer vaccine comprising 13 tumor-associated peptides (TUMAPs) that are frequently found to be over-expressed in the majority of patients suffering from colorectal cancer. These TUMAPs were identified based on the analysis of primary tumor tissue and have been chosen due to their ability to activate cytotoxic T cells and T helper cells against colorectal cancer. As with all immatics’ vaccines, IMA910 has been designed to elicit a strong, clinically relevant immune response to a specific tumor type. The TUMAPs were selected from in over 2,000 peptides identified via immatics’ unique XPRESIDENT™ platform.

       

      About immatics

      immatics biotechnologies is a clinical-stage biopharmaceutical company developing advanced therapeutic vaccines that are active against cancer. immatics’ lead product, IMA901, is in a pivotal Phase III study after completing a successful Phase II trial in renal cell carcinoma. immatics’ pipeline also includes IMA910, in Phase II for colorectal cancer, and IMA950, which is being developed for glioma in Phase I studies.

      immatics’ technology platform rapidly generates defined therapeutic cancer vaccines which are based on multiple tumor-associated peptides (TUMAPs) with the ability to specifically stimulate the immune system against cancer cells. These vaccines – comprising multiple peptides confirmed to be naturally presented by real tumor tissue – offer the prospect of greater effectiveness than existing therapeutic approaches combined with fewer side effects. immatics’ products are ‘drug like’ with stable, off-the-shelf formulations and robust easily scalable manufacturing.

      immatics is based in Tuebingen and Munich, Germany, and has raised €108 million (US$140 million) in private equity in three financing rounds to date, with the last €54 million completed in September 2010.